Dataset Information

Biomarkers of maternal environmental enteric dysfunction are associated with shorter gestation and reduced length in newborn infants in Uganda.

ABSTRACT:

Background

Adverse birth outcomes, including preterm birth and stunting at birth, have long-term health implications. The relation between adverse birth outcomes and chronic, asymptomatic gastrointestinal inflammation (environmental enteric dysfunction-EED) is poorly understood.

Objective

We aimed to examine the relation between maternal EED and adverse birth outcomes in a sample of pregnant Ugandan women and their newborn infants.

Design

We conducted a prospective cohort study in Mukono, Uganda. A total of 258 pregnant women were enrolled at their first prenatal visit (?18 weeks of gestation). EED was measured by urinary lactulose:mannitol (L:M) ratio and serum concentrations of antibodies to the bacterial components flagellin and LPS. Covariates were obtained from survey data collected at 2 time points. Associations were assessed through the use of unadjusted and adjusted simple linear regression models.

Results

Complete birth outcome data were recorded for 220 infants within 48 h of delivery. Mean ± SD gestational age was 39.7 ± 2.1 wk, and 7% were born preterm. Mean ± SD length and length-for-age z score (LAZ) at birth were 48.1 ± 3.2 cm and -0.44 ± 1.07, respectively. L:M ratio was not associated with any birth outcome. In adjusted models, higher concentrations of natural log-transformed anti-flagellin immunoglobin G (IgG) and anti-LPS IgG were significantly associated with shorter length of gestation (?: -0.89 wk; 95% CI: -1.77, -0.01 wk, and ?: -1.01 wk; 95% CI: -1.87, -0.17 wk, respectively) and with reduced length (?: -0.80 cm; 95% CI: -1.55, -0.05 cm, and ?: -0.79 cm; 95% CI: -1.54, -0.04 cm, respectively) and LAZ at birth (? -0.44 z score; 95% CI: -0.83, -0.05, and ?: -0.40 z score; 95% CI: -0.79, -0.01, respectively).

Conclusion

Maternal anti-flagellin and anti-LPS IgG concentrations in pregnancy, but not L:M ratio, were associated with shorter gestation and reduced infant length at birth. Further research on the relation between maternal EED and birth outcomes is warranted.

SUBMITTER: Lauer JM

PROVIDER: S-EPMC6186209 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature

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Publications

Biomarkers of maternal environmental enteric dysfunction are associated with shorter gestation and reduced length in newborn infants in Uganda.

Lauer Jacqueline M JM Duggan Christopher P CP Ausman Lynne M LM Griffiths Jeffrey K JK Webb Patrick P Agaba Edgar E Nshakira Nathan N Tran Hao Q HQ Gewirtz Andrew T AT Ghosh Shibani S

The American journal of clinical nutrition 20181001 4

<h4>Background</h4>Adverse birth outcomes, including preterm birth and stunting at birth, have long-term health implications. The relation between adverse birth outcomes and chronic, asymptomatic gastrointestinal inflammation (environmental enteric dysfunction-EED) is poorly understood.<h4>Objective</h4>We aimed to examine the relation between maternal EED and adverse birth outcomes in a sample of pregnant Ugandan women and their newborn infants.<h4>Design</h4>We conducted a prospective cohort s ...[more]

PMID: 30247538

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Dataset Information

Biomarkers of maternal environmental enteric dysfunction are associated with shorter gestation and reduced length in newborn infants in Uganda.

Background

Objective

Design

Results

Conclusion

Publications

Biomarkers of maternal environmental enteric dysfunction are associated with shorter gestation and reduced length in newborn infants in Uganda.

Similar Datasets

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