YAP/TAZ upstream signals and downstream responses.
Ontology highlight
ABSTRACT:
SUBMITTER: Totaro A
PROVIDER: S-EPMC6186418 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Publications
YAP/TAZ upstream signals and downstream responses.
Totaro Antonio A Panciera Tito T Piccolo Stefano S
Nature cell biology 20180726 8
Cell behaviour is strongly influenced by physical, mechanical contacts between cells and their extracellular matrix. We review how the transcriptional regulators YAP and TAZ integrate mechanical cues with the response to soluble signals and metabolic pathways to control multiple aspects of cell behaviour, including proliferation, cell plasticity and stemness essential for tissue regeneration. Corruption of cell-environment interplay leads to aberrant YAP and TAZ activation that is instrumental f ...[more]
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