Ontology highlight
ABSTRACT:
SUBMITTER: Salter AI
PROVIDER: S-EPMC6186424 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Salter Alexander I AI Ivey Richard G RG Kennedy Jacob J JJ Voillet Valentin V Rajan Anusha A Alderman Eva J EJ Voytovich Uliana J UJ Lin Chenwei C Sommermeyer Daniel D Liu Lingfeng L Whiteaker Jeffrey R JR Gottardo Raphael R Paulovich Amanda G AG Riddell Stanley R SR
Science signaling 20180821 544
Chimeric antigen receptors (CARs) link an antigen recognition domain to intracellular signaling domains to redirect T cell specificity and function. T cells expressing CARs with CD28/CD3ζ or 4-1BB/CD3ζ signaling domains are effective at treating refractory B cell malignancies but exhibit differences in effector function, clinical efficacy, and toxicity that are assumed to result from the activation of divergent signaling cascades. We analyzed stimulation-induced phosphorylation events in primary ...[more]