Ontology highlight
ABSTRACT:
SUBMITTER: Zakharia K
PROVIDER: S-EPMC6187100 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Zakharia Kais K Miyabe Katsuyuki K Wang Yu Y Wu Dehai D Moser Catherine D CD Borad Mitesh J MJ Roberts Lewis R LR
Translational oncology 20181011 1
<h4>Purpose</h4>We investigated the antitumor effect of the casein kinase II (CK2) inhibitor CX-4945 on cholangiocarcinoma (CCA).<h4>Methods</h4>We assessed the effect of CX-4945 alone and/or in combination with gemcitabine and cisplatin on cell viability, colony formation, and apoptosis of CCA cell lines and on in vivo growth of HuCCT1 xenografts.<h4>Results</h4>CX-4945 dose-dependently decreased viability of HuCCT1, EGI-1, and Liv27 and decreased phospho-AKT/total AKT and phospho-PTEN/total PT ...[more]