Ontology highlight
ABSTRACT:
SUBMITTER: Guo YC
PROVIDER: S-EPMC6187217 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
The EMBO journal 20180904 20
The osteogenic differentiation of mesenchymal stem cells (MSCs) is governed by multiple mechanisms. Growing evidence indicates that ubiquitin-dependent protein degradation is critical for the differentiation of MSCs and bone formation; however, the function of ubiquitin-specific proteases, the largest subfamily of deubiquitylases, remains unclear. Here, we identify USP34 as a previously unknown regulator of osteogenesis. The expression of USP34 in human MSCs increases after osteogenic induction ...[more]