Ontology highlight
ABSTRACT:
SUBMITTER: Chen HF
PROVIDER: S-EPMC6187220 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Chen Hui-Feng HF Hsu Chen-Ming CM Huang Yi-Shuian YS
The EMBO journal 20180903 20
Expression of mitochondrial proton transporter uncoupling protein 1 (UCP1) in brown adipose tissue (BAT) is essential for mammalian thermogenesis. While human UCP1 mRNA exists in a long form only, alternative polyadenylation creates two different isoforms in mice with 10% of UCP1 mRNA found in the long form (Ucp1L) and ~90% in the short form (Ucp1S). We generated a mouse model expressing only Ucp1S and found that it showed impaired thermogenesis due to a 60% drop in UCP1 protein levels, suggesti ...[more]