Ontology highlight
ABSTRACT:
SUBMITTER: Pathria G
PROVIDER: S-EPMC6187221 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Pathria Gaurav G Scott David A DA Feng Yongmei Y Sang Lee Joo J Fujita Yu Y Zhang Gao G Sahu Avinash D AD Ruppin Eytan E Herlyn Meenhard M Osterman Andrei L AL Ronai Ze'ev A ZA
The EMBO journal 20180912 20
Nutrient restriction reprograms cellular signaling and metabolic network to shape cancer phenotype. Lactate dehydrogenase A (LDHA) has a key role in aerobic glycolysis (the Warburg effect) through regeneration of the electron acceptor NAD<sup>+</sup> and is widely regarded as a desirable target for cancer therapeutics. However, the mechanisms of cellular response and adaptation to LDHA inhibition remain largely unknown. Here, we show that LDHA activity supports serine and aspartate biosynthesis. ...[more]