Ontology highlight
ABSTRACT:
SUBMITTER: Yao H
PROVIDER: S-EPMC6187402 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Yao Hong H Wei Guoxiang G Liu Yanpeng Y Yao Hequan H Zhu Zheying Z Ye Wencai W Wu Xiaoming X Xu Jinyi J Xu Shengtao S
ACS medicinal chemistry letters 20180925 10
23-Hydroxybetulinic acid (23-HBA) is a complex lupane triterpenoid, which has attracted increasing attention as an anticancer agent. However, its detailed mechanism of anticancer action remains elusive so far. To reveal its anticancer mode of action, a series of fluorescent 23-HBA derivatives conjugated with coumarin dyes were designed, synthesized, and evaluated for their antiproliferative activities. Subcellular localization and uptake profile studies of representative fluorescent 23-HBA probe ...[more]