Ontology highlight
ABSTRACT:
SUBMITTER: Jentsch NG
PROVIDER: S-EPMC6187413 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
ACS medicinal chemistry letters 20180914 10
HIV-1 integrase multimerization inhibitors have recently been established as an effective class of antiretroviral agents due to their potent ability to inhibit viral replication. Specifically, quinoline-based inhibitors have been shown to effectively impair HIV-1 replication, highlighting the importance of these heterocyclic scaffolds. Pursuant of our endeavors to further develop a library of quinoline-based candidates, we have implemented a structure-activity relationship study of trisubstitute ...[more]