Ontology highlight
ABSTRACT:
SUBMITTER: Wu H
PROVIDER: S-EPMC6188231 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Wu Hao H Downs Deborah D Ghosh Koena K Ghosh Arun K AK Staib Peter P Monod Michel M Tang Jordan J
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20130219 6
Systemic infection by the pathogenic yeast Candida albicans produces high mortality in immune-compromised people. Such infection starts with the penetration of the organism at the mucosal surfaces, facilitated by the secreted aspartic proteases (Saps) 4, 5, and 6. The functional mechanism of these virulence factors is unclear. We discovered that Saps 4-6 each contains amino acid motifs RGD/KGD to bind integrins on epithelial cell A549 and are internalized to endosomes and lysosomes. These proces ...[more]