Ontology highlight
ABSTRACT:
SUBMITTER: Rotem A
PROVIDER: S-EPMC6188569 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Molecular biology and evolution 20181001 10
Viral evolutionary pathways are determined by the fitness landscape, which maps viral genotype to fitness. However, a quantitative description of the landscape and the evolutionary forces on it remain elusive. Here, we apply a biophysical fitness model based on capsid folding stability and antibody binding affinity to predict the evolutionary pathway of norovirus escaping a neutralizing antibody. The model is validated by experimental evolution in bulk culture and in a drop-based microfluidics t ...[more]