Ontology highlight
ABSTRACT:
SUBMITTER: Park J
PROVIDER: S-EPMC6188645 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Park Jihwan J Shrestha Rojesh R Qiu Chengxiang C Kondo Ayano A Huang Shizheng S Werth Max M Li Mingyao M Barasch Jonathan J Suszták Katalin K
Science (New York, N.Y.) 20180405 6390
Our understanding of kidney disease pathogenesis is limited by an incomplete molecular characterization of the cell types responsible for the organ's multiple homeostatic functions. To help fill this knowledge gap, we characterized 57,979 cells from healthy mouse kidneys by using unbiased single-cell RNA sequencing. On the basis of gene expression patterns, we infer that inherited kidney diseases that arise from distinct genetic mutations but share the same phenotypic manifestation originate fro ...[more]