Ontology highlight
ABSTRACT:
SUBMITTER: Deng Q
PROVIDER: S-EPMC6189144 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Deng Qing Q Hou Jianbing J Feng Liying L Lv Ailing A Ke Xiaoxue X Liang Hanghua H Wang Feng F Zhang Kui K Chen Kuijun K Cui Hongjuan H
Cell death & disease 20181015 11
PHD finger protein 19 (PHF19), a critical component of the polycomb repressive complex 2 (PRC2), is crucial for maintaining the repressive transcriptional activity of several developmental regulatory genes and plays essential roles in various biological processes. Abnormal expression of PHF19 causes dysplasia or serious diseases, including chronic myeloid disorders and tumors. However, the biological functions and molecular mechanisms of PHF19 in glioblastoma (GBM) remain unclear. Here, we demon ...[more]