Ontology highlight
ABSTRACT:
SUBMITTER: Mu L
PROVIDER: S-EPMC6189171 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Mu Libing L Tu Zhongyuan Z Miao Lin L Ruan Hefei H Kang Ning N Hei Yongzhen Y Chen Jiahuan J Wei Wei W Gong Fangling F Wang Bingjie B Du Yanan Y Ma Guanghui G Amerein Matthias W MW Xia Tie T Shi Yan Y
Nature communications 20181015 1
Phagocytosis is one of the earliest cellular functions, developing approximately 2 billion years ago. Although FcR-based phagocytic signaling is well-studied, how it originated from ancient phagocytosis is unknown. Lipid redistribution upregulates a phagocytic program recapitulating FcR-based phagocytosis with complete dependence on Src family kinases, Syk, and phosphoinositide 3-kinases (PI3K). Here we show that in phagocytes, an atypical ITAM sequence in the ancient membrane anchor protein Moe ...[more]