Ontology highlight
ABSTRACT:
SUBMITTER: Vojinovic D
PROVIDER: S-EPMC6189289 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Vojinovic Dina D Kavousi Maryam M Ghanbari Mohsen M Brouwer Rutger W W RWW van Rooij Jeroen G J JGJ van den Hout Mirjam C G N MCGN Kraaij Robert R van Ijcken Wilfred F J WFJ Uitterlinden Andre G AG van Duijn Cornelia M CM Amin Najaf N
Frontiers in genetics 20181009
Carotid intima-media thickness (cIMT) is an established heritable marker for subclinical atherosclerosis. In this study, we aim to identify rare variants with large effects driving differences in cIMT by performing genome-wide linkage analysis of individuals in the extremes of cIMT trait distribution (>90th percentile) in a large family-based study from a genetically isolated population in the Netherlands. Linked regions were subsequently explored by fine-mapping using exome sequencing. We obser ...[more]