Ontology highlight
ABSTRACT:
SUBMITTER: Motojima F
PROVIDER: S-EPMC6190516 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Motojima Fumihiro F Fujii Katsuya K Yoshida Masasuke M
Journal of biochemistry 20181101 5
Chaperonins assist folding of many cellular proteins, including essential proteins for cell viability. However, it remains unclear how chaperonin-assisted folding is different from spontaneous folding. Chaperonin GroEL/GroES facilitates folding of denatured protein encapsulated in its central cage but the denatured protein often escapes from the cage to the outside during reaction. Here, we show evidence that the in-cage-folding and the escape occur diverging from the same intermediate complex i ...[more]