Ontology highlight
ABSTRACT:
SUBMITTER: Mihaylova VT
PROVIDER: S-EPMC6190718 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Mihaylova Valia T VT Kong Yong Y Fedorova Olga O Sharma Lokesh L Dela Cruz Charles S CS Pyle Anna Marie AM Iwasaki Akiko A Foxman Ellen F EF
Cell reports 20180901 11
Rhinovirus is a leading cause of acute respiratory infections and asthma attacks, but infections are also frequently cleared from the nasal mucosa without causing symptoms. We sought to better understand host defense against rhinovirus by investigating antiviral defense in primary human nasal and bronchial airway epithelial cells cultured ex vivo. Surprisingly, upon rhinovirus infection or RIG-I stimulation, nasal-derived epithelial cells exhibited much more robust antiviral responses than bronc ...[more]