Ontology highlight
ABSTRACT:
SUBMITTER: Richardson BG
PROVIDER: S-EPMC6190829 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Richardson Benjamin G BG Jain Atul D AD Potteti Haranatha R HR Lazzara Phillip R PR David Brian P BP Tamatam Chandra R CR Choma Ewelina E Skowron Kornelia K Dye Katherine K Siddiqui Zamia Z Wang Yue-Ting YT Krunic Aleksej A Reddy Sekhar P SP Moore Terry W TW
Journal of medicinal chemistry 20180831 17
Activators of nuclear factor-erythroid 2-related factor 2 (NRF2) could lead to promising therapeutics for prevention and treatment of oxidative stress and inflammatory disorders. Ubiquitination and subsequent degradation of the transcription factor NRF2 is mediated by Kelch-like ECH-associated protein-1 (KEAP1). Inhibition of the KEAP1/NRF2 interaction with small molecules leads to NRF2 activation. Previously, we and others described naphthalene-based NRF2 activators, but the 1,4-diaminonaphthal ...[more]