Ontology highlight
ABSTRACT:
SUBMITTER: Sarkar S
PROVIDER: S-EPMC6191418 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Sarkar Susobhan S Poon Candice C CC Mirzaei Reza R Rawji Khalil S KS Hader Walter W Bose Pinaki P Kelly John J Dunn Jeffrey F JF Yong V Wee VW
Scientific reports 20181016 1
We reported previously that microglia decreased the growth of human brain tumor-initiating cells (BTICs). Through microarray analyses of BTICs exposed in vitro to microglia, we found the induction of several genes ascribed to have roles in cell cycle arrest, reduced cell proliferation and differentiation. Herein, we tested the hypothesis that one of these genes, growth arrest specific 1 (Gas1), is a novel growth reduction factor that is induced in BTICs by microglia. We found that microglia incr ...[more]