Unknown

Dataset Information

0

Cellular and Molecular Immune Response to Chikungunya Virus Infection.

ABSTRACT: Chikungunya virus (CHIKV) is a re-emergent arthropod-borne virus (arbovirus) that causes a disease characterized primarily by fever, rash and severe persistent polyarthralgia. In the last decade, CHIKV has become a serious public health problem causing several outbreaks around the world. Despite the fact that CHIKV has been around since 1952, our knowledge about immunopathology, innate and adaptive immune response involved in this infectious disease is incomplete. In this review, we provide an updated summary of the current knowledge about immune response to CHIKV and about soluble immunological markers associated with the morbidity, prognosis and chronicity of this arbovirus disease. In addition, we discuss the progress in the research of new vaccines for preventing CHIKV infection and the use of monoclonal antibodies as a promising therapeutic strategy.

SUBMITTER: Tanabe ISB 

PROVIDER: S-EPMC6191487 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Chikungunya virus (CHIKV) is a re-emergent arthropod-borne virus (arbovirus) that causes a disease characterized primarily by fever, rash and severe persistent polyarthralgia. In the last decade, CHIKV has become a serious public health problem causing several outbreaks around the world. Despite the fact that CHIKV has been around since 1952, our knowledge about immunopathology, innate and adaptive immune response involved in this infectious disease is incomplete. In this review, we provide an u  ...[more]

Similar Datasets

Unknown Chronic joint disease caused by persistent Chikungunya virus infection is controlled by the adaptive immune response.
| S-EPMC3838294 | biostudies-literature
Unknown Highly functional virus-specific cellular immune response in asymptomatic SARS-CoV-2 infection.
| S-EPMC7927662 | biostudies-literature
Unknown Comprehensive innate immune profiling of chikungunya virus infection in pediatric cases.
| S-EPMC6110311 | biostudies-literature
Unknown Imported chikungunya virus infection.
| S-EPMC2874343 | biostudies-literature
Transcriptomics Chikungunya Virus Time Course Infection of Human Macrophages
2022-03-02 | GSE182287 | GEO
Unknown Multiple immune factors are involved in controlling acute and chronic chikungunya virus infection.
| S-EPMC4256279 | biostudies-literature
Unknown Chikungunya virus infection: molecular biology, clinical characteristics, and epidemiology in Asian countries.
| S-EPMC8638460 | biostudies-literature
Transcriptomics Transcriptomics of Aedes aegypti derived Aag2 cells in response to chikungunya virus infection
2022-04-11 | GSE195852 | GEO
Unknown Host immune response to mosquito-transmitted chikungunya virus differs from that elicited by needle inoculated virus.
| S-EPMC2920837 | biostudies-literature
Unknown Chikungunya virus requires cellular chloride channels for efficient genome replication.
| S-EPMC6746389 | biostudies-other