Impact of CDX2 expression status on the survival of patients after curative resection for colorectal cancer liver metastasis.

ABSTRACT:

Background

The prognostic biomarker for patients undergoing curative liver metastasectomy for colorectal cancer (CRC) is lacking. The purpose was to investigate the prognostic role of a lack of CDX2 expression, which has been proposed as a potential biomarker for high-risk relapse in early-stage CRC, in patients undergoing curative liver metastasectomy.

Methods

A total of 396 consecutive patients with CRC liver metastasis who underwent potentially curative liver metastasectomy at a single center in Japan between 2005 and 2015 were included. For the immunohistochemical analysis of nuclear CDX2 expression, we adopted the tissue microarray approach using the resected metastatic liver CRCs. Patient subgroups were compared with respect to disease-free survival (DFS) and overall s

SUBMITTER: Shigematsu Y 

PROVIDER: S-EPMC6192098 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature