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Encoding function into polypeptide-oligonucleotide precision biopolymers.

ABSTRACT: We report a novel synthesis strategy to prepare precision polymers providing exact chain lengths, molecular weights and monomer sequences that allow post modifications by convenient DNA hybridization. Two grafted single strand DNA (ssDNA) side chains serve as a versatile platform for sequence-specific attachment of chromophores, proteins, cell-targeting peptide, and a Y-shape DNA linker. This approach resembles a LEGO®-type incorporation of functionalities to create functional biopolymers of high structure definition under mild conditions.

SUBMITTER: Liu W

PROVIDER: S-EPMC6192144 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature

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Encoding function into polypeptide-oligonucleotide precision biopolymers.

Liu Weina W Boldt Felix F Tokura Yu Y Wang Tao T Agrawalla Bikram Keshari BK Wu Yuzhou Y Weil Tanja T

Chemical communications (Cambridge, England) 20181001 83

We report a novel synthesis strategy to prepare precision polymers providing exact chain lengths, molecular weights and monomer sequences that allow post modifications by convenient DNA hybridization. Two grafted single strand DNA (ssDNA) side chains serve as a versatile platform for sequence-specific attachment of chromophores, proteins, cell-targeting peptide, and a Y-shape DNA linker. This approach resembles a LEGO®-type incorporation of functionalities to create functional biopolymers of hig ...[more]

PMID: 30280162

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