Ontology highlight
ABSTRACT:
SUBMITTER: Abbate F
PROVIDER: S-EPMC6192859 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Abbate Franco F Badal Brateil B Mendelson Karen K Aydin Iraz T IT Serasinghe Madhavika N MN Iqbal Ramiz R Mohammed Jarvier N JN Solovyov Alexander A Greenbaum Benjamin D BD Chipuk Jerry E JE Celebi Julide T JT
Pigment cell & melanoma research 20180429 5
FBXW7 is well characterized as a tumor suppressor in many human cancers including melanoma; however, the mechanisms of tumor-suppressive function have not been fully elucidated. We leveraged two distinct RNA sequencing datasets: human melanoma cell lines (n = 10) with control versus silenced FBXW7 and a cohort of human melanoma tumor samples (n = 51) to define the transcriptomic fingerprint regulated by FBXW7. Here, we report that loss of FBXW7 enhances a mitochondrial gene transcriptional progr ...[more]