Ontology highlight
ABSTRACT:
SUBMITTER: Thompson PA
PROVIDER: S-EPMC6192870 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Leukemia 20180417 11
Achieving undetectable MRD (U-MRD) status after chemoimmunotherapy predicts longer progression-free and overall survival. The predictive factors and timing of relapse in patients with U-MRD and value of interim MRD analysis are ill-defined. This was a prospective study of 289 patients with CLL treated first-line with FCR. MRD analysis was performed after course 3 (C3) and at end of therapy (EOT) in bone marrow using 4-color flow cytometry (sensitivity 10<sup>-4</sup>). Eighteen percent of patien ...[more]