Ontology highlight
ABSTRACT:
SUBMITTER: Flores CT
PROVIDER: S-EPMC6192988 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Nature communications 20181017 1
Immune checkpoint blockade using anti-PD-1 monoclonal antibodies has shown considerable promise in the treatment of solid tumors, but brain tumors remain notoriously refractory to treatment. In CNS malignancies that are completely resistant to PD-1 blockade, we found that bone marrow-derived, lineage-negative hematopoietic stem and progenitor cells (HSCs) that express C-C chemokine receptor type 2 (CCR2<sup>+</sup>) reverses treatment resistance and sensitizes mice to curative immunotherapy. HSC ...[more]