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Ventrolateral but not Dorsolateral Prefrontal Cortex tDCS effectively impact emotion reappraisal - effects on Emotional Experience and Interbeat Interval.

ABSTRACT: Emotions can be understood as behavioral, physiological, and subjective individual's alteration due to a given situation. Several times, an efficient regulation of these emotions can promote psychological and social survival. It has been demonstrated that the Prefrontal Cortex (PFC) presents a relevant role in cognitive control, especially during emotion regulation strategies. However, evidence for the role of the PFC and emotional regulation comes mostly from neuroimaging experiments lacking from causal information. Transcranial Direct Current Stimulation (tDCS) has been shown to be an efficient noninvasive neuromodulation technique capable to address causal hypothesis. The aim of this study was to investigate the role of two regions of the PFC (Dorsolateral and Ventrolateral region) on different strategies of emotional reappraisal during the observation of negative images. 180 undergraduate students (mean age 21,75?±?3,38) participated in this study, divided in two experiments (Dorsolateral PFC - n?=?90; Ventrolateral PFC - n?=?90). As not expected, DLPFC tDCS did not modulate the responses on the emotional regulation task. However, VLPFC tDCS resulted in less negative valence of negative images as well as decreased cardiac interbeat interval on earlier moments of emotional processing. These findings supports the general view about the role of the PFC on emotional regulation and, at the same time, advances the field by providing evidence that evaluation of negative stimuli is much more based on the VLPFC than on the DLPCF.

SUBMITTER: Marques LM

PROVIDER: S-EPMC6193012 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature

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Ventrolateral but not Dorsolateral Prefrontal Cortex tDCS effectively impact emotion reappraisal - effects on Emotional Experience and Interbeat Interval.

Marques Lucas M LM Morello Letícia Y N LYN Boggio Paulo S PS

Scientific reports 20181017 1

Emotions can be understood as behavioral, physiological, and subjective individual's alteration due to a given situation. Several times, an efficient regulation of these emotions can promote psychological and social survival. It has been demonstrated that the Prefrontal Cortex (PFC) presents a relevant role in cognitive control, especially during emotion regulation strategies. However, evidence for the role of the PFC and emotional regulation comes mostly from neuroimaging experiments lacking fr ...[more]

PMID: 30333566

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Project description:OBJECTIVES:Implicit regulation of emotions involves medial-prefrontal cortex (mPFC) regions exerting regulatory control over limbic structures. Diminished regulation relates to aberrant mPFC functionality and psychopathology. Establishing means of modulating mPFC functionality could benefit research on emotion and its dysregulation. Here, we tested the capacity of transcranial direct current stimulation (tDCS) targeting mPFC to modulate subjective emotional states by facilitating implicit emotion regulation. MATERIALS AND METHODS:Stimulation was applied concurrently with functional magnetic resonance imaging to validate its neurobehavioral effect. Sixteen participants were each scanned twice, counterbalancing active and sham tDCS application, while undergoing negative mood induction (clips featuring negative vs. neutral contents). Effects of stimulation on emotional experience were assessed using subjective and neural measures. RESULTS:Subjectively, active stimulation led to significant reduction in reported intensity of experienced emotions to negatively valenced (p?=?0.005) clips but not to neutral clips (p?>?0.99). Active stimulation further mitigated a rise in stress levels from pre- to post-induction (sham: p?=?0.004; active: p?=?0.15). Neurally, stimulation increased activation in mPFC regions associated with implicit emotion regulation (ventromedial-prefrontal cortex; subgenual anterior-cingulate cortex, sgACC), and in ventral striatum, a core limbic structure (all ps?<?0.05). Stimulation also altered functional connectivity (assessed using whole-brain psycho-physiological interaction) between these regions, and with additional limbic regions. Stimulation-induced sgACC activation correlated with reported emotion intensity and depressive symptoms (rs?>?0.64, ps?<?0.018), suggesting individual differences in stimulation responsivity. CONCLUSIONS:Results of this study indicate the potential capacity of tDCS to facilitate brain activation in mPFC regions underlying implicit regulation of emotion and accordingly modulate subjective emotional experiences.

Dataset Information

Ventrolateral but not Dorsolateral Prefrontal Cortex tDCS effectively impact emotion reappraisal - effects on Emotional Experience and Interbeat Interval.

Publications

Ventrolateral but not Dorsolateral Prefrontal Cortex tDCS effectively impact emotion reappraisal - effects on Emotional Experience and Interbeat Interval.

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