Ontology highlight
ABSTRACT:
SUBMITTER: Clark CR
PROVIDER: S-EPMC6193042 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Clark Christopher R CR Maile Makayla M Blaney Patrick P Hellweg Stefano R SR Strauss Anna A Durose Wilaiwan W Priya Sambhawa S Habicht Juri J Burns Michael B MB Blekhman Ran R Abrahante Juan E JE Starr Timothy K TK
Scientific reports 20181017 1
New therapeutic targets for advanced colorectal cancer (CRC) are critically needed. Our laboratory recently performed an insertional mutagenesis screen in mice to identify novel CRC driver genes and, thus, potential drug targets. Here, we define Transmembrane 9 Superfamily 2 (TM9SF2) as a novel CRC oncogene. TM9SF2 is an understudied protein, belonging to a well conserved protein family characterized by their nine putative transmembrane domains. Based on our transposon screen we found that TM9SF ...[more]