Ontology highlight
ABSTRACT:
SUBMITTER: Domingo J
PROVIDER: S-EPMC6193533 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Domingo Júlia J Diss Guillaume G Lehner Ben B
Nature 20180530 7708
A central question in genetics and evolution is the extent to which the outcomes of mutations change depending on the genetic context in which they occur<sup>1-3</sup>. Pairwise interactions between mutations have been systematically mapped within<sup>4-18</sup> and between <sup>19</sup> genes, and have been shown to contribute substantially to phenotypic variation among individuals <sup>20</sup> . However, the extent to which genetic interactions themselves are stable or dynamic across genotype ...[more]