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Recent experience impacts social behavior in a novel context by adult zebrafish (Danio rerio).

ABSTRACT: Many animals exhibit behavioral plasticity as they move between habitats seasonally, reside in fluctuating environments, or respond to human-induced environmental change. We know that physical environment during early development can have a lasting impact on behavior, and on the neural mechanisms that shape behavior. In adults, social context can have similar persistent effects on behavior and the brain. Here, we asked whether physical context impacts adult social behavior in a novel environment. We placed groups of adult zebrafish (Danio rerio) in two different physical contexts. After two weeks, we measured group behavior in a novel context, and found that zebrafish with recent experience in a more-complex physical environment charged each other more often and tended to form tighter shoals than did fish that had been housed in less-complex environments. These differences were present regardless of the novel context in which we assayed behavior, and were not easily explained by differences in activity level. Our results demonstrate the impact of recent experiences on adult behavior, and highlight the importance of physical as well as social history in predicting animal behavior in novel situations.

SUBMITTER: Sykes DJ

PROVIDER: S-EPMC6193632 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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Recent experience impacts social behavior in a novel context by adult zebrafish (Danio rerio).

Sykes Delawrence J DJ Suriyampola Piyumika S PS Martins Emília P EP

PloS one 20181018 10

Many animals exhibit behavioral plasticity as they move between habitats seasonally, reside in fluctuating environments, or respond to human-induced environmental change. We know that physical environment during early development can have a lasting impact on behavior, and on the neural mechanisms that shape behavior. In adults, social context can have similar persistent effects on behavior and the brain. Here, we asked whether physical context impacts adult social behavior in a novel environment ...[more]

PMID: 30335773

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Project description:The zebrafish (Danio rerio) is an established model organism in pharmacology and biomedicine, including in research on alcohol use disorders and alcohol-related disease. In the past 2 decades, zebrafish has been used to study the complex effects of ethanol on the vertebrate brain and behavior in both acute, chronic and developmental exposure paradigms. Sex differences in the neurobehavioral response to ethanol are well documented for humans and rodents, yet no consensus has been reached for zebrafish. Here, we show for the first time that male zebrafish of the AB strain display more severe behavioral impairments than females for equal exposure concentrations. Adult zebrafish were immersed in 0, 1 or 2% (v/v) ethanol for 30 min, after which behavior was individually assessed in the zebrafish Multivariate Concentric Square Field™ (zMCSF) arena. Males exposed to 2% ethanol showed clear signs of sedation, including reduced activity, increased shelter seeking and reduced exploration of shallow zones. The 1% male group displayed effects in the same direction but of smaller magnitude; this group also explored the shallow areas less, but did not show a general reduction in activity nor an increase in shelter seeking. By contrast, 1 and 2% exposed females showed no alterations in explorative behavior. Females exposed to 2% ethanol did not display a general reduction in activity, rather activity gradually increased from hypoactivity to hyperactivity over the course of the test. This mixed stimulatory/depressant effect was only quantifiable when locomotory variables were analyzed over time and was not apparent from averages of the whole 30-min test, which may explain why previous studies failed to detect sex-specific effects on locomotion. Our results emphasize the importance of explicitly including sex and time as factors in pharmacological studies of zebrafish behavior. We hypothesize that the lower sensitivity of female zebrafish to ethanol may be explained by their greater body weight and associated larger distribution volume for ethanol, which may render lower brain ethanol concentrations in females.

Dataset Information

Recent experience impacts social behavior in a novel context by adult zebrafish (Danio rerio).

Publications

Recent experience impacts social behavior in a novel context by adult zebrafish (Danio rerio).

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