Ontology highlight
ABSTRACT:
SUBMITTER: Chiang DY
PROVIDER: S-EPMC6193872 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Circulation 20181001 15
<h4>Background</h4>Heart failure (HF) is a complex disease with a rising prevalence despite advances in treatment. Protein phosphatase 1 (PP1) has long been implicated in HF pathogenesis, but its exact role is both unclear and controversial. Most previous studies measured only the PP1 catalytic subunit (PP1c) without investigating its diverse set of interactors, which confer localization and substrate specificity to the holoenzyme. In this study, we define the PP1 interactome in cardiac tissue a ...[more]