Global long non-coding RNA expression in the rostral anterior cingulate cortex of depressed suicides.

ABSTRACT: Long non-coding RNAs (lncRNAs) are an emerging class of regulatory RNA that may be implicated in psychiatric disorders. Here we performed RNA-sequencing in the rostral anterior cingulate cortex of 26 depressed suicides and 24 matched controls. We first performed differential lncRNA expression analysis, and then conducted Weighted Gene Co-expression Network Analysis (WGCNA) to identify co-expression modules associating with depression and suicide. We identified 23 differentially expressed lncRNAs (FDR?

SUBMITTER: Zhou Y 

PROVIDER: S-EPMC6193959 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature