Global long non-coding RNA expression in the rostral anterior cingulate cortex of depressed suicides.
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ABSTRACT:
SUBMITTER: Zhou Y
PROVIDER: S-EPMC6193959 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
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Global long non-coding RNA expression in the rostral anterior cingulate cortex of depressed suicides.
Zhou Yi Y Lutz Pierre-Eric PE Wang Yu Chang YC Ragoussis Jiannis J Turecki Gustavo G
Translational psychiatry 20181018 1
Long non-coding RNAs (lncRNAs) are an emerging class of regulatory RNA that may be implicated in psychiatric disorders. Here we performed RNA-sequencing in the rostral anterior cingulate cortex of 26 depressed suicides and 24 matched controls. We first performed differential lncRNA expression analysis, and then conducted Weighted Gene Co-expression Network Analysis (WGCNA) to identify co-expression modules associating with depression and suicide. We identified 23 differentially expressed lncRNAs ...[more]
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