Ontology highlight
ABSTRACT:
SUBMITTER: Oosterheert W
PROVIDER: S-EPMC6194020 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Oosterheert Wout W van Bezouwen Laura S LS Rodenburg Remco N P RNP Granneman Joke J Förster Friedrich F Mattevi Andrea A Gros Piet P
Nature communications 20181018 1
Enzymes of the six-transmembrane epithelial antigen of the prostate (STEAP) family reduce Fe<sup>3+</sup> and Cu<sup>2+</sup> ions to facilitate metal-ion uptake by mammalian cells. STEAPs are highly upregulated in several types of cancer, making them potential therapeutic targets. However, the structural basis for STEAP-catalyzed electron transfer through an array of cofactors to metals at the membrane luminal side remains elusive. Here, we report cryo-electron microscopy structures of human ST ...[more]