Persistent mRNA and miRNA expression changes in irradiated baboons.
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ABSTRACT:
SUBMITTER: Port M
PROVIDER: S-EPMC6194144 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Publications
Persistent mRNA and miRNA expression changes in irradiated baboons.
Port Matthias M Hérodin Francis F Valente Marco M Drouet Michel M Ostheim Patrick P Majewski Matthäus M Abend Michael M
Scientific reports 20181018 1
We examined the transcriptome/post-transcriptome for persistent gene expression changes after radiation exposure in a baboon model. Eighteen baboons were irradiated with a whole body equivalent dose of 2.5 or 5 Gy. Blood samples were taken before, 7, 28 and 75-106 days after radiation exposure. Stage I was a whole genome screening for mRNA combined with a qRT-PCR platform for detection of 667 miRNAs. Candidate mRNAs and miRNAs differentially up- or down-regulated in stage I were chosen for valid ...[more]
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