Ontology highlight
ABSTRACT: Objective
The aim of this study was to explore the relationship between low-density lipoprotein cholesterol:high-density lipoprotein cholesterol (LDL-C:HDL-C) ratio and common carotid atherosclerotic plaque (CCAP) among obese adults of Uygur community in Xinjiang, China.Design
A hospital-based cross-sectional study.Setting
First Affiliated Hospital of Xinjiang Medical University.Participants
A total of 1449 obese adults of Uygur population who were free of coronary artery disease were included in our study from 1 January 2014 to 31 December 2016.Methodology
Lipid profiles, other routine laboratory parameters and intima-media thickness of the common carotid artery were measured in all participants. Multivariate logistic regression analysis was used to examine the association between LDL-C:HDL-C ratio and CCAP.Results
Four hundred and fifteen (28.64%) participants had CCAP. Participants with CCAP had significantly higher LDL-C:HDL-C ratio compared with those without CCAP (3.21 [2.50, 3.88] vs 2.33 [1.95, 2.97], p<0.001). Multivariate logistic regression analysis showed high LDL-C:HDL-C ratio as independent predictor of CCAP after adjusting for conventional cardiovascular risk factors. The top LDL-C:HDL-C ratio quartile (?3.25) had an OR of 9.355 (95% CI 6.181 to 14.157) compared with the bottom quartile (<2.07) of LDL-C:HDL-C ratio (p<0.001) after adjustment for age, body mass index, smoking, diabetes mellitus and serum level of total cholesterol.Conclusion
CCAP is highly prevalent in Uygur obese adults. A high LDL-C:HDL-C ratio is an independent predictor of CCAP. It may help identify obese individuals who are at high risk of CCAP and who may benefit from intensive LDL-lowering therapy.
SUBMITTER: Zhao Q
PROVIDER: S-EPMC6194467 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Zhao Qiang Q Liu Fen F Wang Ying-Hong YH Lai Hong-Mei HM Zhao Qian Q Luo Jun-Yi JY Ma Yi-Tong YT Li Xiao-Mei XM Yang Yi-Ning YN
BMJ open 20181008 10
<h4>Objective</h4>The aim of this study was to explore the relationship between low-density lipoprotein cholesterol:high-density lipoprotein cholesterol (LDL-C:HDL-C) ratio and common carotid atherosclerotic plaque (CCAP) among obese adults of Uygur community in Xinjiang, China.<h4>Design</h4>A hospital-based cross-sectional study.<h4>Setting</h4>First Affiliated Hospital of Xinjiang Medical University.<h4>Participants</h4>A total of 1449 obese adults of Uygur population who were free of coronar ...[more]