Dataset Information

Neuroinflammation is induced by tongue-instilled ZnO nanoparticles via the Ca²⁺-dependent NF-?B and MAPK pathways.

ABSTRACT:

Background

The extensive biological applications of zinc oxide nanoparticles (ZnO NPs) in stomatology have created serious concerns about their biotoxicity. In our previous study, ZnO NPs were confirmed to transfer to the central nervous system (CNS) via the taste nerve pathway and cause neurodegeneration after 30 days of tongue instillation. However, the potential adverse effects on the brain caused by tongue-instilled ZnO NPs are not fully known.

Methods

In this study, the biodistribution of Zn, cerebral histopathology and inflammatory responses were analysed after 30 days of ZnO NPs tongue instillation. Moreover, the molecular mechanisms underlying neuroinflammation in vivo were further elucidated by treating BV2 and PC12 cells with ZnO NPs in vitro.

Results

This analysis indicated that ZnO NPs can transfer into the CNS, activate glial cells and cause neuroinflammation after tongue instillation. Furthermore, exposure to ZnO NPs led to a reduction in cell viability and induction of inflammatory response and calcium influx in BV2 and PC12 cells. The mechanism underlying how ZnO NPs induce neuroinflammation via the Ca²⁺-dependent NF-?B, ERK and p38 activation pathways was verified at the cytological level.

Conclusion

This study provided a new way how NPs, such as ZnO NPs, induce neuroinflammation via the taste nerve translocation pathway, a new mechanism for ZnO NPs-induced neuroinflammation and a new direction for nanomaterial toxicity analysis.

SUBMITTER: Liang H

PROVIDER: S-EPMC6194560 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature

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Publications

Neuroinflammation is induced by tongue-instilled ZnO nanoparticles via the Ca<sup>2+</sup>-dependent NF-κB and MAPK pathways.

Liang Huimin H Chen Aijie A Lai Xuan X Liu Jia J Wu Junrong J Kang Yiyuan Y Wang Xinying X Shao Longquan L

Particle and fibre toxicology 20181019 1

<h4>Background</h4>The extensive biological applications of zinc oxide nanoparticles (ZnO NPs) in stomatology have created serious concerns about their biotoxicity. In our previous study, ZnO NPs were confirmed to transfer to the central nervous system (CNS) via the taste nerve pathway and cause neurodegeneration after 30 days of tongue instillation. However, the potential adverse effects on the brain caused by tongue-instilled ZnO NPs are not fully known.<h4>Methods</h4>In this study, the biodi ...[more]

PMID: 30340606

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Dataset Information

Neuroinflammation is induced by tongue-instilled ZnO nanoparticles via the Ca²⁺-dependent NF-?B and MAPK pathways.

Background

Methods

Results

Conclusion

Publications

Neuroinflammation is induced by tongue-instilled ZnO nanoparticles via the Ca<sup>2+</sup>-dependent NF-κB and MAPK pathways.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Dataset Information

Neuroinflammation is induced by tongue-instilled ZnO nanoparticles via the Ca2+-dependent NF-?B and MAPK pathways.

Background

Methods

Results

Conclusion

Publications

Neuroinflammation is induced by tongue-instilled ZnO nanoparticles via the Ca<sup>2+</sup>-dependent NF-κB and MAPK pathways.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Neuroinflammation is induced by tongue-instilled ZnO nanoparticles via the Ca²⁺-dependent NF-?B and MAPK pathways.