Genotoxic and epigenotoxic effects in mice exposed to concentrated ambient fine particulate matter (PM_2.5) from Sao Paulo city, Brazil.

ABSTRACT:

Background

The Metropolitan Area of São Paulo has a unique composition of atmospheric pollutants, and positive correlations between exposure and the risk of diseases and mortality have been observed. Here we assessed the effects of ambient fine particulate matter (PM_2.5) on genotoxic and global DNA methylation and hydroxymethylation changes, as well as the activities of antioxidant enzymes, in tissues of AJ mice exposed whole body to ambient air enriched in PM_2.5, which was concentrated in a chamber near an avenue of intense traffic in São Paulo City, Brazil.

Results

Mice exposed to concentrated ambient PM_2.5 (1 h daily, 3 months) were compared to in situ ambient air exposed mice as the study control. The concentrated PM_2.5 exposed

SUBMITTER: de Oliveira AAF 

PROVIDER: S-EPMC6194750 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature