Ontology highlight
ABSTRACT:
SUBMITTER: Crewe C
PROVIDER: S-EPMC6195477 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Cell 20181004 3
We have uncovered the existence of extracellular vesicle (EV)-mediated signaling between cell types within the adipose tissue (AT) proper. This phenomenon became evident in our attempts at generating an adipocyte-specific knockout of caveolin 1 (cav1) protein. Although we effectively ablated the CAV1 gene in adipocytes, cav1 protein remained abundant. With the use of newly generated mouse models, we show that neighboring endothelial cells (ECs) transfer cav1-containing EVs to adipocytes in vivo, ...[more]