Ontology highlight
ABSTRACT:
SUBMITTER: Veldkamp MW
PROVIDER: S-EPMC6195571 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Veldkamp Marieke W MW Geuzebroek Guillaume S C GSC Baartscheer Antonius A Verkerk Arie O AO Schumacher Cees A CA Suarez Gedeon G GG Berger Wouter R WR Casini Simona S van Amersfoorth Shirley C M SCM Scholman Koen T KT Driessen Antoine H G AHG Belterman Charly N W CNW van Ginneken Antoni C G ACG de Groot Joris R JR de Bakker Jacques M T JMT Remme Carol Ann CA Boukens Bas J BJ Coronel Ruben R
Nature communications 20181019 1
The cardiac autonomic nervous system (ANS) controls normal atrial electrical function. The cardiac ANS produces various neuropeptides, among which the neurokinins, whose actions on atrial electrophysiology are largely unknown. We here demonstrate that the neurokinin substance-P (Sub-P) activates a neurokinin-3 receptor (NK-3R) in rabbit, prolonging action potential (AP) duration through inhibition of a background potassium current. In contrast, ventricular AP duration was unaffected by NK-3R act ...[more]