Ontology highlight
ABSTRACT:
SUBMITTER: Robert BM
PROVIDER: S-EPMC6195614 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Robert Beaulah Mary BM Dakshinamoorthy Muralidharan M Ganapathyagraharam Ramamoorthy Brindha B Dhandapani Muthu M Thangaiyan Radhiga R Muthusamy Ganesan G Nirmal R Madhavan RM Prasad Nagarajan Rajendra NR
Scientific reports 20181019 1
Oral Squamous Cell Carcinoma (OSCC) patients respond poorly to chemotherapy. We analyzed the expression of 11 drug response-related genes in 31 OSCC biopsies, collected prior to any treatment, using custom-designed PCR array. Further, we investigated the drug response pattern of selected anticancer drugs by BH3 (Bcl2 Homology-3) profiling in the primary cells isolated from OSCC tissues. Then, we correlated the results of drug-response gene expression pattern with apoptotic priming to predict tum ...[more]