Metabolic inflexibility in women with PCOS is similar to women with type 2 diabetes.

ABSTRACT: Background:An ability to switch between primarily oxidizing fat in the fasted state to carbohydrate in the fed state, termed metabolic flexibility, is associated with insulin sensitivity. Metabolic flexibility has been explored previously in women with polycystic ovary syndrome (PCOS), yet the independent or synergistic contributions of androgen excess and/or insulin resistance is not yet known. Therefore, the purpose of this article was to characterize metabolic flexibility in women with PCOS compared to women of normal BMI, obesity, or type 2 diabetes (T2DM). Methods:Eighty-six weight-stable women; thirty with either PCOS (n?=?30), or fifty-six with obesity (n?=?12), T2DM (n?=?27), or normal BMI (n?=?17) underwent a hyperinsulinemic euglycemic clamp and indirect calorimetry to measure insulin sensitivity and substrate oxidation via indirect calorimetry, respectively. Results:All analyses were adjusted for differences in age, ethnicity, and BMI between groups. Women with PCOS were less metabolically flexible compared to healthy women with obesity (p?

SUBMITTER: Broskey NT 

PROVIDER: S-EPMC6195988 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature