Unknown

Dataset Information

0

Helicobacter pylori seropositivity and its association with incident all-cause and Alzheimer's disease dementia in large national surveys.


ABSTRACT: INTRODUCTION:Infectious agents were recently implicated in Alzheimer's disease (AD) and etiology of other dementias, notably Helicobacter pylori. METHODS:We tested associations of H. pylori seropositivity with incident all-cause and AD dementia and with AD-related mortality among US adults in a retrospective cohort study. Data from the National Health and Nutrition Surveys III, phase 1 (1988-1991) and 1999-2000 linked with Medicare and National Death Index registries, were used (baseline age ?45 y, follow-up to 2013, Npooled = 5927). RESULTS:A positive association between H. pylori seropositivity and AD mortality was found in men (hazard ratioadj, pooled = 4.33, 95% confidence interval: 1.51-12.41, P = .006), which was replicated for incident AD and all-cause dementia, with hazard ratioadj, pooled = 1.45 (95% confidence interval: 1.03-2.04, P = .035) and hazard ratioadj, III = 1.44 (95% confidence interval: 1.05-1.98, P = .022), respectively. These associations were also positive among higher socioeconomic status groups. DISCUSSION:In sum, H. pylori seropositivity's direct association with AD mortality, all-cause dementia, and AD dementia was restricted to men and to higher socioeconomic status groups.

SUBMITTER: Beydoun MA 

PROVIDER: S-EPMC6196325 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature

altmetric image

Publications

Helicobacter pylori seropositivity and its association with incident all-cause and Alzheimer's disease dementia in large national surveys.

Beydoun May A MA   Beydoun Hind A HA   Elbejjani Martine M   Dore Gregory A GA   Zonderman Alan B AB  

Alzheimer's & dementia : the journal of the Alzheimer's Association 20180628 9


<h4>Introduction</h4>Infectious agents were recently implicated in Alzheimer's disease (AD) and etiology of other dementias, notably Helicobacter pylori.<h4>Methods</h4>We tested associations of H. pylori seropositivity with incident all-cause and AD dementia and with AD-related mortality among US adults in a retrospective cohort study. Data from the National Health and Nutrition Surveys III, phase 1 (1988-1991) and 1999-2000 linked with Medicare and National Death Index registries, were used (b  ...[more]

Similar Datasets

| S-EPMC3679320 | biostudies-literature
| S-EPMC3858455 | biostudies-literature
| S-EPMC7493958 | biostudies-literature
| S-EPMC10551451 | biostudies-literature
| S-EPMC7019483 | biostudies-literature
| S-EPMC10208692 | biostudies-literature
| S-EPMC9530585 | biostudies-literature
| S-EPMC8949269 | biostudies-literature
| S-EPMC10984501 | biostudies-literature
| 2582311 | ecrin-mdr-crc