(1-aryloxy-2-hydroxypropyl)-phenylpiperazine derivatives suppress Candida albicans virulence by interfering with morphological transition.
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ABSTRACT:
SUBMITTER: Zhao S
PROVIDER: S-EPMC6196381 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
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(1-aryloxy-2-hydroxypropyl)-phenylpiperazine derivatives suppress Candida albicans virulence by interfering with morphological transition.
Zhao Shuo S Huang Jun-Jun JJ Sun Xiuyun X Huang Xiaorong X Fu Shuna S Yang Liang L Liu Xue-Wei XW He Fei F Deng Yinyue Y
Microbial biotechnology 20180917 6
Clinical treatment of Candida albicans infections has become more difficult due to the limited development of antifungal agents and the rapid emergence of drug resistance. In this study, we demonstrate the synthesis of a series of piperazine derivatives and the evaluation of their inhibitory activity against C. albicans virulence. Thirty-four (1-aryloxy-2-hydroxypropyl)-phenylpiperazine derivatives, including 25 new compounds, were synthesized and assessed for their efficacy against the physiolo ...[more]
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