Ontology highlight
ABSTRACT:
SUBMITTER: Weng PJ
PROVIDER: S-EPMC6196489 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Weng Peter J PJ Gao Yang Y Gregory Mark T MT Wang Pengcheng P Wang Yinsheng Y Yang Wei W
Proceedings of the National Academy of Sciences of the United States of America 20181001 42
Oxidatively induced DNA lesions 8,5'-cyclopurine-2'-deoxynucleosides (cdPus) are prevalent and cytotoxic by impeding DNA replication and transcription. Both the 5'<i>R</i>- and 5'<i>S</i>-diastereomers of cdPu can be removed by nucleotide excision repair; however, the 5'<i>S</i>-cdPu is more resistant to repair than the 5'<i>R</i> counterpart. Here, we report the crystal structures of human polymerase (Pol) η bypassing 5'<i>S</i>-8,5'-cyclo-2'-deoxyadenosine (cdA) in insertion and the following ...[more]