Ontology highlight
ABSTRACT:
SUBMITTER: Lin W
PROVIDER: S-EPMC6196501 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Lin Wenlong W Su Fasheng F Gautam Rahul R Wang Ning N Zhang Yuanyuan Y Wang Xiaojian X
Proceedings of the National Academy of Sciences of the United States of America 20181003 42
The signaling cascades triggered by the cross-linkage of immunoglobulin E (IgE) with its high-affinity receptor (FcεRI) on mast cells contribute to multiple allergic disorders, such as asthma, rhinitis, and atopic dermatitis. Restraint of intracellular signals for mast cell activation is essential to restore homeostasis. In this study, we found that Raf kinase inhibitor protein (RKIP) negatively regulated mast cell activation. RKIP-deficient mast cells showed greater IgE-FcεRI-mediated activatio ...[more]