Ontology highlight
ABSTRACT:
SUBMITTER: Barcellos SH
PROVIDER: S-EPMC6196527 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Barcellos Silvia H SH Carvalho Leandro S LS Turley Patrick P
Proceedings of the National Academy of Sciences of the United States of America 20181002 42
This work investigates whether genetic makeup moderates the effects of education on health. Low statistical power and endogenous measures of environment have been obstacles to the credible estimation of such gene-by-environment interactions. We overcome these obstacles by combining a natural experiment that generated variation in secondary education with polygenic scores for a quarter-million individuals. The additional schooling affected body size, lung function, and blood pressure in middle ag ...[more]