Ontology highlight
ABSTRACT: Objective
Foetuses and neonates of women who use tobacco are exposed to nicotine and tobacco-derived carcinogens. We determined the relationship between urine biomarkers of tobacco toxicant exposure postpartum and in the neonates of Alaska Native (AN) women, comparing smokers and smokeless tobacco (ST) users, including iqmik, a homemade ST product.Methods
AN women, including 36 smokers, 9 commercial ST and 16 iqmik users their neonates participated. Urine from the woman at the time of delivery and her neonate's first urine were analysed for cotinine, the major metabolite of nicotine, and 4-(methylnitrosamino)-1-(3) pyridyl-1-butanol (NNAL), a tobacco-specific carcinogen biomarker.Results
Maternal urine cotinine and neonatal urine cotinine were strongly correlated in all tobacco use groups (r from 0.83 to 0.9, p < 0.002). Correlations between maternal cotinine and neonatal NNAL were moderately strong for cigarettes and commercial smokeless but weaker for iqmik users (r 0.73, 0.6 and 0.36, respectively).Conclusion
Correlations between maternal and neonatal biomarkers of tobacco toxicant exposure vary, dependent on tobacco product use.Significance
This study provides novel data on biomarkers of tobacco exposure among postpartum AN women and their neonates. The results could be useful to guide future epidemiological studies of health risks associated with use of various tobacco products during pregnancy.
SUBMITTER: Benowitz NL
PROVIDER: S-EPMC6197029 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Benowitz Neal L NL Flanagan Christie A CA Thomas Timothy K TK Koller Kathryn R KR Wolfe Abbie W AW Renner Caroline C CC Hughes Christine C Decker Paul A PA Hatsukami Dorothy K DK Murphy Neil J NJ Patten Christi C
International journal of circumpolar health 20181201 1
<h4>Objective</h4>Foetuses and neonates of women who use tobacco are exposed to nicotine and tobacco-derived carcinogens. We determined the relationship between urine biomarkers of tobacco toxicant exposure postpartum and in the neonates of Alaska Native (AN) women, comparing smokers and smokeless tobacco (ST) users, including iqmik, a homemade ST product.<h4>Methods</h4>AN women, including 36 smokers, 9 commercial ST and 16 iqmik users their neonates participated. Urine from the woman at the ti ...[more]