APOE ?2 is associated with increased tau pathology in primary tauopathy.
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ABSTRACT:
SUBMITTER: Zhao N
PROVIDER: S-EPMC6197187 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
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APOE ε2 is associated with increased tau pathology in primary tauopathy.
Zhao Na N Liu Chia-Chen CC Van Ingelgom Alexandra J AJ Linares Cynthia C Kurti Aishe A Knight Joshua A JA Heckman Michael G MG Diehl Nancy N NN Shinohara Mitsuru M Martens Yuka A YA Attrebi Olivia N ON Petrucelli Leonard L Fryer John D JD Wszolek Zbigniew K ZK Graff-Radford Neill R NR Caselli Richard J RJ Sanchez-Contreras Monica Y MY Rademakers Rosa R Murray Melissa E ME Koga Shunsuke S Dickson Dennis W DW Ross Owen A OA Bu Guojun G
Nature communications 20181022 1
Apolipoprotein E (APOE) ε4 allele is the strongest genetic risk factor for late-onset Alzheimer's disease mainly by modulating amyloid-β pathology. APOE ε4 is also shown to exacerbate neurodegeneration and neuroinflammation in a tau transgenic mouse model. To further evaluate the association of APOE genotype with the presence and severity of tau pathology, we express human tau via an adeno-associated virus gene delivery approach in human APOE targeted replacement mice. We find increased hyperpho ...[more]
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