ZZ-dependent regulation of p62/SQSTM1 in autophagy.
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ABSTRACT:
SUBMITTER: Zhang Y
PROVIDER: S-EPMC6197226 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Publications
ZZ-dependent regulation of p62/SQSTM1 in autophagy.
Zhang Yi Y Mun Su Ran SR Linares Juan F JF Ahn JaeWoo J Towers Christina G CG Ji Chang Hoon CH Fitzwalter Brent E BE Holden Michael R MR Mi Wenyi W Shi Xiaobing X Moscat Jorge J Thorburn Andrew A Diaz-Meco Maria T MT Kwon Yong Tae YT Kutateladze Tatiana G TG
Nature communications 20181022 1
Autophagic receptor p62 is a critical mediator of cell detoxification, stress response, and metabolic programs and is commonly deregulated in human diseases. The diverse functions of p62 arise from its ability to interact with a large set of ligands, such as arginylated (Nt-R) substrates. Here, we describe the structural mechanism for selective recognition of Nt-R by the ZZ domain of p62 (p62<sub>ZZ</sub>). We show that binding of p62<sub>ZZ</sub> to Nt-R substrates stimulates p62 aggregation an ...[more]
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