HIV Entry and Its Inhibition by Bifunctional Antiviral Proteins.
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ABSTRACT:
SUBMITTER: Falkenhagen A
PROVIDER: S-EPMC6197789 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Publications
HIV Entry and Its Inhibition by Bifunctional Antiviral Proteins.
Falkenhagen Alexander A Joshi Sadhna S
Molecular therapy. Nucleic acids 20180911
HIV entry is a highly specific and time-sensitive process that can be divided into receptor binding, coreceptor binding, and membrane fusion. Bifunctional antiviral proteins (bAVPs) exploit the multi-step nature of the HIV entry process by binding to two different extracellular targets. They are generated by expressing a fusion protein containing two entry inhibitors with a flexible linker. The resulting fusion proteins exhibit exceptional neutralization potency and broad cross-clade inhibition. ...[more]
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