Ontology highlight
ABSTRACT:
SUBMITTER: Withers SS
PROVIDER: S-EPMC6197816 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Developmental and comparative immunology 20180531
While dogs are increasingly being utilized as large-animal models of disease, important features of age-related immunosenescence in the dog have yet to be evaluated due to the lack of defined naïve vs. memory T lymphocyte phenotypes. We therefore performed multi-color flow cytometry on peripheral blood mononuclear cells from young and aged beagles, and determined the differential cytokine production by proposed memory subsets. CD4+ and CD8+ T lymphocytes in aged dogs displayed increased cytokine ...[more]